DNA-fueled molecular machine for label-free and non-enzymatic ultrasensitive detection of telomerase activity.
نویسندگان
چکیده
Herein, a non-enzymatic and label-free strategy based on DNA-fueled molecular machine was developed for ultrasensitive detection of telomerase activity in cancer cell extracts even at the single-cell level.
منابع مشابه
Label-free ultrasensitive detection of telomerase activity via multiple telomeric hemin/G-quadruplex triggered polyaniline deposition and a DNA tetrahedron-structure regulated signal.
Label-free detection of telomerase activity was done by using telomeric hemin/G-quadruplex triggered polyaniline deposition, not only on themselves but also on the DNA tetrahedron-structure (DTS). DTS size has a great impact on telomerase accessibility, reactivity and detection sensitivity. The method has been used to evaluate bladder cancer development.
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عنوان ژورنال:
- The Analyst
دوره 141 16 شماره
صفحات -
تاریخ انتشار 2016